Illuminating the Biochemical Activity Architecture of the Cell

Abstract number
96
Presentation Form
Invited
Corresponding Email
[email protected]
Session
Live and Functional Imaging Technologies Part 2
Authors
Jin Zhang (1)
Affiliations
1. University of California
Abstract text

The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation and dynamic modulation of the activities of signaling molecules, such as protein kinases, phosphatases and second messengers. We have developed a series of fluorescent biosensors to probe the compartmentalized signaling activities in living cells. In this talk, I will discuss a suite of newly developed fluorescent biosensors and present a study where we applied these genetically encoded fluorescent biosensors to probe the biochemical activity architecture of the cell.