Illuminating the Biochemical Activity Architecture of the Cell

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Live and Functional Imaging Technologies Part 2
Jin Zhang (1)
1. University of California
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The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation and dynamic modulation of the activities of signaling molecules, such as protein kinases, phosphatases and second messengers. We have developed a series of fluorescent biosensors to probe the compartmentalized signaling activities in living cells. In this talk, I will discuss a suite of newly developed fluorescent biosensors and present a study where we applied these genetically encoded fluorescent biosensors to probe the biochemical activity architecture of the cell.